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The fda reviewed reports of lactic acidosis associated with the use of the diabetes drug metformin glucophage occurring from may 1995 through june 30, 1996, the drug s first year on the market in the u.

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A reduction of diabetic complications has been shown in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failuresee section 5.1

High feverwater pillsdiuretics such as hydrochlorothiazidetoo much sweatingdiarrheaor vomiting may cause loss of too much body waterdehydrationand increase your risk of lactic acidosisStop taking this medication and tell your doctor right away if you have prolonged diarrhea or vomitingBe sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofsevere breathing problemssuch as obstructive lung diseasesevere asthmablood problemssuch as anemiavitamin B12 deficiencykidney diseaseliver disease.

Factors that may increase the risk of lactic acidosissee section 4.4should be reviewed before considering initiation of metformin.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofsevere breathing problemssuch as obstructive lung diseasesevere asthmablood problemssuch as anemiavitamin B12 deficiencykidney diseaseliver disease.

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the team looked at several popular classes of oral diabetes medication metformin sold as glucophage, fortamet and others , second-generation sulfonylureas amaryl, glucotrol and more , thiazolidinediones avandia and actos and meglitinides starlix and prandin and added two new classes of drugs, dipeptidyl peptidase-4 dpp-4 inhibitors januvia and onglynza and glucagon-like peptide-1 glp-1 receptor agonists byetta and victoza , which are given by injection.

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