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While taking Eldepryl and for 14 days after you stopyou must NOT eat foods that are high in tyramineincluding:

An antidepressantcitalopramdesvenlafaxineduloxetineescitalopramfluvoxaminelevomilnacipranmilnacipranmirtazapinenefazodoneparoxetinevenlafaxinevilazodonevortioxetineand othersor.

Some medicines can cause unwanted or dangerous effects when used with EldeprylYour doctor may need to change your treatment plan if you use any of the following drugs:

Consequentlyit may be useful to inform patientsor their familiesabout the signs and symptoms associated with MAOI induced hypertensive reactionsIn particularpatients should be urged to reportimmediatelyany severe headache or other atypical or unusual symptoms not previously experienced.

Assessment of the carcinogenic potential of selegiline in mice and rats is ongoing for all dosage formsSelegiline did not induce mutations or chromosomal damage when tested in the bacterial mutation assay in Salmonella typhimurium and in an in vivo chromosomal aberration assayWhile these studies provide some reassurance that selegiline is not mutagenic or clastogenicthey are not definitive because of methodological limitationsNo definitive in vitro chromosomal aberration or in vitro mammalian gene mutation assays have been performed.

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in theory, since mao-a of the gut is not inhibited, patients treated with eldepryl at a dose of 10 mg a day should be able to take medications containing pharmacologically active amines and consume tyramine-containing foods without risk of uncontrolled hypertension.

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