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Lactic acid buildup in the bloodlactic acidosisand sometimes fatal liver disease have occurred with the use of lamivudine-HBVused both alone and in combination with other drugs for treating human immunodeficiency virusHIVinfection.

In controlled clinical trialsYMDD-mutant HBV was detected in subjects with on-Epivir-HBV re-appearance of HBV DNA after an initial decline below the solution-hybridization assay limitsee Microbiology12.4Subjects treated with Epivir-HBVadults and childrenwith YMDD-mutant HBV at 52 weeks showed diminished treatment responses in comparison with subjects treated with Epivir-HBV without evidence of YMDD substitutionsincluding the followinglower rates of HBeAg seroconversion and HBeAg lossno greater than placebo recipientsmore frequent return of positive HBV DNAand more frequent ALT elevationsIn the controlled trialswhen subjects developed YMDD-mutant HBVthey had a rise in HBV DNA and ALT from their own previous on-treatment levelsProgression of hepatitis Bincluding deathhas been reported in some subjects with YMDD-mutant HBVincluding subjects from the liver transplant setting and from other clinical trialsIn clinical practicemonitoring of ALT and HBV DNA levels during treatment with Epivir-HBV may aid in treatment decisions if emergence of viral mutants is suspected.

The Epivir brand contains a higher dose of lamivudine than Epivir-HBV brandEpivir is for treating HIV and Epivir-HBV is for treating hepatitis BEach time you get a refill of this medicationbe sure you have received the correct brand to treat your condition.

Epivir-HBV is not FDA approved for treatment of HIV-1 infectionlamivudine dosage in EPIVIR-HBV is subtherapeutic and monotherapy is inappropriate for the treatment of HIV-1 infection and the safety and efficacy of this drug have not been established in patients co-infected with HBV and HIVsevere acute exacerbations of hepatitis B reported in patients who have discontinued anti-hepatitis B therapyincluding HBV formulationhepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who discontinue anti-hepatitis B therapyif appropriateinitiation of anti-hepatitis B therapy may be warranted.

Epivir is for treating HIVthe virus that can cause acquired immunodeficiency syndromeAIDSEpivir is not a cure for HIV or AIDS.

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following 52 weeks of epivir-hbv plus adefovir dipivoxil combination therapy n 46 or therapy with only epivir-hbv n 49 , ymdd mutant hbv was detected less frequently in subjects receiving combination therapy, 62 versus 96 .

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