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For adults with epilepsy, the daily dosage should not exceed keppra xr 3000 mg.

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Table 9 lists adverse reactions that occurred in at least 5of idiopathic generalized epilepsy patients experiencing PGTC seizures treated with KEPPRA and were numerically more common than in patients treated with placeboIn this studyeither KEPPRA or placebo was added to concurrent AED therapy.

Table 9Adverse Reactions in a Placebo-ControlledAdd-On Study in Patients 4 Years of Age and Older with PGTC Seizures.

Potential pharmacokinetic interactions of or with levetiracetam were assessed in clinical pharmacokinetic studiesphenytoinvalproatewarfarindigoxinoral contraceptiveprobenecidand through pharmacokinetic screening in the placebo-controlled clinical studies in epilepsy patients.

KEPPRA can cause anaphylaxis or angioedema after the first dose or at any time during treatmentSigns and symptoms in cases reported in the postmarketing setting have included hypotensionhivesrashrespiratory distressand swelling of the facelipmoutheyetonguethroatand feetIn some reported casesreactions were lifethreatening and required emergency treatmentIf a patient develops signs or symptoms of anaphylaxis or angioedemaKEPPRA should be discontinued and the patient should seek immediate medical attentionKEPPRA should be discontinued permanently if a clear alternative etiology for the reaction cannot be establishedsee CONTRAINDICATIONS

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common side effects of keppra include dizziness, spinning sensation, drowsiness, irritability, and headache.

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