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Fluvoxamine luvox , ketoconazole nizoral and cimetidine tagamet may increase the levels of mirtazapine in the blood which may lead to increased side effects from mirtazapine.

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Serious hepatotoxicityincluding cases with a fatal outcome or requiring liver transplantationhas occurred with the use of oral ketoconazoleSome patients had no obvious risk factors for liver diseaseSerious hepatotoxicity was reported both by patients receiving high doses for short treatment durations and by patients receiving low doses for long durations.

Disopyramidedofetilidedronedaroneeplerenonenisoldipinequinidineor ranolazine;

Ketoconazole has been used in high doses for the treatment of advanced prostate cancer and for Cushing’s syndrome when other treatment options have failedThe safety and effectiveness of ketoconazole have not been established in these settings and the use of ketoconazole for these indications is not approved by FDA.

General Disorders and Administration Site Conditionsastheniafatiguehot flushmalaiseedema peripheralpyrexiachills Investigationsplatelet count decreased.

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