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MAXZIDEtriamterene and hydrochlorothiazideis a diureticantihypertensive drug productprincipally due to its hydrochlorothiazide componentthe triamterene component of MAXZIDE reduces the excessive potassium loss which may occur with hydrochlorothiazide use.

Fluid and electrolyte imbalances are the most important concernExcessive doses of the triamterene component may elicit hyperkalemiadehydrationnauseavomiting and weakness and possibly hypotensionOverdosing with hydrochlorothiazide has been associated with hypokalemiahypochloremiahyponatremiadehydrationlethargymay progress to comaand gastrointestinal irritationTreatment is symptomatic and supportiveTherapy with MAXZIDEtriamterene and hydrochlorothiazideshould be discontinuedInduce emesis or institute gastric lavageMonitor serum electrolyte levels and fluid balance.

Insulin requirements in diabetic patients may be increaseddecreased or unchangedDiabetes mellitus which has been latent may become manifest during thiazide administration.

The safe use of MAXZIDE in pregnancy has not been established since there are no adequate and well controlled studies with MAXZIDE in pregnant womenMAXZIDE should be used during pregnancy only if the potential benefit justifies the risk to the fetus.

During pregnancythis medication should be used only when clearly neededIt may harm an unborn babyDiscuss the risks and benefits with your doctor.

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midamor amiloride should not be given to patients receiving other potassium-conserving agents, such as spironolactone or triamterene.

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