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In a small study comparing men and womenless inhibition of ADP-induced platelet aggregation was observed in women.
A randomizedplacebo-controlled trialCLARINETdid not demonstrate a clinical benefit of clopidogrel in neonates and infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary arterial shuntPossible factors contributing to this outcome were the dose of clopidogrelthe concomitant administration of aspirin and the late initiation of therapy following shunt palliationIt cannot be ruled out that a trial with a different design would demonstrate a clinical benefit in this patient population.
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